A catalytic metal-free Ritter reaction to 3-substituted 3-aminooxindoles.
نویسندگان
چکیده
The first Ritter reaction of 3-substituted 3-hydroxyoxindoles with nitriles, catalyzed by HClO(4), is developed, which enables the synthesis of 3-substituted 3-aminooxindoles in good to excellent yield with rich diversity.
منابع مشابه
Maleimide as an efficient nucleophilic partner in the aza-Morita-Baylis-Hillman reaction: synthesis of chiral 3-substituted-3-aminooxindoles.
A highly enantioselective Morita-Baylis-Hillman reaction of maleimides with isatin derived ketimines has been developed to obtain enantiomerically enriched 3-substituted-3-aminooxindoles using β-isocupreidine as an organocatalyst. Maleimide acting as a nucleophile provides products with up to 99% ee.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 16 شماره
صفحات -
تاریخ انتشار 2012